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  • Publication Date: January 17, 1973
  • Publication Number: GB-1303019-A

Abstract

1303019 Dioxolanes DELALANDE SA 13 Dec 1971 [7 Jan 1971] 57712/71 Heading C2C Compounds of the general formula (R 1,2 =C 1-3 alkyl or -NR 1 R 2 = 1-pyrrolidinyl, piperidino, morpholino) and their acid addition salts are prepared by reacting epibromohydrin with 3,4,5-trimethoxyacetophenone in the presence of stannic chloride and in carbon tetrachloride, and reacting the resulting 2-methyl- 4 - bromomethyl - 2 - (3<SP>1</SP>,4<SP>1</SP>,5<SP>1</SP> - trimethoxyphenyl)-dioxolane with R 1 R 2 NH., optionally followed by salt formation. The above compounds possess spasmolytic, choleretic, hypotensive, peripheral vasodilatory and antiarhythmic properties, and may be administered in the form of pharmaceutical preparations containing them in association with a carrier.

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